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Senior Scientist, Pharmacology Job. Job in Bedford, Massachusetts, United States in Celgene Corporation. Nelest.com
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Senior Scientist, Pharmacology Job

col-narrow-left   

Job ID:

23210

Location:

Bedford, MA 

Job function:

Research & Development
col-narrow-right   

Posted:

03.11.2016

Employment Type:

Full time

Industry:

Healthcare / Pharma
col-wide   

Title:

Senior Scientist, Pharmacology Job

Job Description:

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture.

Summary/Scope
The Senior Scientist, Pharmacology will provide scientific support to the discovery organization by providing knowledge and experience in in vivo proof of principle support and biomarker selection for small molecule target validation, specifically in the immunology/inflammation disease area. The pharmacologist will work with the Sr. Director of Preclinical Sciences to provide guidance and expertise to discovery teams, and will assure a quality product delivery for team decision making. The pharmacologist will also be required to identify outsourcing facilities (CROs) to facilitate in vivo pharmacology that is an area of that CRO's expertise. The pharmacologist will need to communicate timing, budget and monitor the study conduct, as appropriate.

Responsibilities will include, but are not limited to, the following:
1. Design and conduct in vivo studies in rodents to establish PK/PD relationships, and in vivo proof of concept for target validation in an immunology/inflammation-focused discovery environment.
2. Identify CROs or other collaborations that could enable models or apply expertise that is not available inhouse. Collaborate, monitor and report CRO based studies to discovery project teams.
3. Directly enable the conduct of in vivo studies, as well as the ability to supervise/mentor other scientists/associates in the pharmacology group.
4. Data collection in electronic notebook or in hardcopy laboratory notebooks is critical.
5. Serve as a Principal Investigator on IACUC protocols. Able to draft protocols and present clearly to IACUC committee.
6. Participates in discovery teams to provide expertise and knowledge from the pharmacology discipline. Helps identify relevant models and works within team to establish workplan for in vivo PK/PD and pharmacology support.
7. Communicate effectively within group to establish clear priorities and seek alignment on a workplan that meets discovery team needs
8. Collaborate with pharmacology group at other Celgene sites to assure that best practices are used to evaluate targets in discovery from an in vivo perspective.

*LI-KM1

Job Requirements:


Prerequisites:

PhD in Pharmacology, Animal Science, or a related biological discipline with >, 5 years relevant pharmaceutical R&D experience. Previous experience with design and execution of preclinical pharmacology studies, particularly in immunology, to support multiple indications in inflammatory diseases is required. Knowledge of incorporation of relevant biomarkers in preclinical proof of concept studies is required. Previous experience managing internal and externally conducted studies and monitoring study conduct and reporting is highly desired.

Skills/Knowledge Required:
- Solid understand of immunology discovery research, focused primarily on in vivo and ex vivo evaluations of small molecules targeted to immune/inflammatory disease targets.
- Ability to provide expertise and guidance to discovery project teams with regard to animal models of disease and relevant PK/PD and biomarker assessments. Knowledge of the literature and current science in pharmacology assessments
- Ability to generate high quality data in a dynamic high paced environment
- Knowledge of outsourcing CROs and monitoring of studies at outsourced sites
- Experience in in vivo study conduct, animal handling, husbandry, dosing by multiple routes, observation recording, blood, tissue collection and limited necropsy.

- Ability to generate protocols, and record data in a notebook (electronic or hardcopy)

Skills/Knowledge Desired:

- Knowledge of immunology/inflammation, oncology, immune-oncology desired
- Knowledge of in vitro assessment of pharmacologic activity

Personal characteristics
- S trong presence as well as sense of urgency and priorities as well as flexibility. The ability and strong desire to 'make things happen'.
- Decisive as well as collaborative.
- High level of honesty and integrity.
- Excellent interpersonal skills with particular emphasis on communication & relationship building.
- Motivated to be part of an organization that aims to make a difference through cutting edge research.
Passion for the pharmaceutical industry.

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

Travel: Yes, 5 % of the Time

Zip Code:

01730

Company Info
Celgene Corporation
86 Morris Avenue
Summit, NJ, United States

Phone: +1-908-673-9000, +41 32 729 85 00, 1-908-673-9800, 1-908-673-9800
Web Site: www.celgene.com

Company Profile

Company Info


Celgene Corporation
86 Morris Avenue
Summit, NJ, United States
Phone: +1-908-673-9000, +41 32 729 85 00, 1-908-673-9800, 1-908-673-9800
Web Site: www.celgene.com

Senior Scientist, Pharmacology Job

col-narrow-left   

Job ID:

23210

Location:

Bedford, MA 

Job function:

Research & Development
col-narrow-right   

Posted:

03.11.2016

Employment Type:

Full time

Industry:

Healthcare / Pharma
col-wide   

Title:

Senior Scientist, Pharmacology Job

Job Description:

Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture.

Summary/Scope
The Senior Scientist, Pharmacology will provide scientific support to the discovery organization by providing knowledge and experience in in vivo proof of principle support and biomarker selection for small molecule target validation, specifically in the immunology/inflammation disease area. The pharmacologist will work with the Sr. Director of Preclinical Sciences to provide guidance and expertise to discovery teams, and will assure a quality product delivery for team decision making. The pharmacologist will also be required to identify outsourcing facilities (CROs) to facilitate in vivo pharmacology that is an area of that CRO's expertise. The pharmacologist will need to communicate timing, budget and monitor the study conduct, as appropriate.

Responsibilities will include, but are not limited to, the following:
1. Design and conduct in vivo studies in rodents to establish PK/PD relationships, and in vivo proof of concept for target validation in an immunology/inflammation-focused discovery environment.
2. Identify CROs or other collaborations that could enable models or apply expertise that is not available inhouse. Collaborate, monitor and report CRO based studies to discovery project teams.
3. Directly enable the conduct of in vivo studies, as well as the ability to supervise/mentor other scientists/associates in the pharmacology group.
4. Data collection in electronic notebook or in hardcopy laboratory notebooks is critical.
5. Serve as a Principal Investigator on IACUC protocols. Able to draft protocols and present clearly to IACUC committee.
6. Participates in discovery teams to provide expertise and knowledge from the pharmacology discipline. Helps identify relevant models and works within team to establish workplan for in vivo PK/PD and pharmacology support.
7. Communicate effectively within group to establish clear priorities and seek alignment on a workplan that meets discovery team needs
8. Collaborate with pharmacology group at other Celgene sites to assure that best practices are used to evaluate targets in discovery from an in vivo perspective.

*LI-KM1

Job Requirements:


Prerequisites:

PhD in Pharmacology, Animal Science, or a related biological discipline with >, 5 years relevant pharmaceutical R&D experience. Previous experience with design and execution of preclinical pharmacology studies, particularly in immunology, to support multiple indications in inflammatory diseases is required. Knowledge of incorporation of relevant biomarkers in preclinical proof of concept studies is required. Previous experience managing internal and externally conducted studies and monitoring study conduct and reporting is highly desired.

Skills/Knowledge Required:
- Solid understand of immunology discovery research, focused primarily on in vivo and ex vivo evaluations of small molecules targeted to immune/inflammatory disease targets.
- Ability to provide expertise and guidance to discovery project teams with regard to animal models of disease and relevant PK/PD and biomarker assessments. Knowledge of the literature and current science in pharmacology assessments
- Ability to generate high quality data in a dynamic high paced environment
- Knowledge of outsourcing CROs and monitoring of studies at outsourced sites
- Experience in in vivo study conduct, animal handling, husbandry, dosing by multiple routes, observation recording, blood, tissue collection and limited necropsy.

- Ability to generate protocols, and record data in a notebook (electronic or hardcopy)

Skills/Knowledge Desired:

- Knowledge of immunology/inflammation, oncology, immune-oncology desired
- Knowledge of in vitro assessment of pharmacologic activity

Personal characteristics
- S trong presence as well as sense of urgency and priorities as well as flexibility. The ability and strong desire to 'make things happen'.
- Decisive as well as collaborative.
- High level of honesty and integrity.
- Excellent interpersonal skills with particular emphasis on communication & relationship building.
- Motivated to be part of an organization that aims to make a difference through cutting edge research.
Passion for the pharmaceutical industry.

Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.

Travel: Yes, 5 % of the Time

Zip Code:

01730
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